Increased oxidative stress is considered to be one of the key factors leading to aging and neurodegenerative diseases, but it is not clear why oxidative stress can accumulate in the nervous system and affect the function of the nervous system. A new study by the research team led by Chi-Kuang Yao, an assistant research fellow at the Institute of Biological Chemistry, found a new model of oxidative stress propagation. This team demonstrated that oxidative stress can promote its own formation and further damage entire motor nervous system function through the special connectivity of the motor circuit. This achievement will open a new window for future research on motor system dysfunction caused by aging and motor neuron diseases. The paper has been published in eLife on July.